Prevention of hepatorenal toxicity with Sonchus asper in gentamicin treated rats
نویسندگان
چکیده
منابع مشابه
Prevention of hepatorenal toxicity with Sonchus asper in gentamicin treated rats
BACKGROUND Sonchus asper possesses antioxidant capacity and is used in liver and kidney disorders. We have investigated the preventive effect of methanolic extract of Sonchus asper (SAME) on the gentamicin induced alterations in biochemical and morphological parameters in liver and kidneys of Sprague-Dawley male rat. METHODS Acute oral toxicity studies were performed for selecting the therape...
متن کاملComparison of the Nutritive Value, Antioxidant and Antibacterial Activities of Sonchus asper and Sonchus oleraceus
Many local vegetable materials are under-exploited because of inadequate scientific knowledge of their nutritional potentials. For this reason, the nutritional, phytochemical, antioxidant and antibacterial activities of the acetone, methanol and water extracts of the leaves of Sonchus asper and Sonchus oleraceus were investigated. The proximate analysis showed that the plants contained apprecia...
متن کاملEvaluation of the Chemical Composition of Sonchus eruca and Sonchus asper
Sonchus eruca and Sonchus asper were analyzed for their chemical evaluation, vitamins and bioactive secondary metabolite. The results revealed the presence of bioactive constituents comprising alkaloids (1.24 to 1.34 mg/100 g), saponins (1.46 to 1.72 mg/100 g), flavonoids (1.61 to 1.34mg/100 g), phenols (1.32 to1.44 mg/100g), saponins (0.12 to 0.41mg/100 g) and tannins (0.02 to 0.61 mg/100g). T...
متن کاملEvaluation of urinary enzymes in newborns treated with gentamicin
Objective(s): In recent years, there has been an increasing amount of study on early diagnosis of kidney injury through sensitive and specific biomarkers. We examined the practical applicability of the urinary levels of NAG (N-acetyl-β-D-glucosaminidase), AP (alkaline phosphatase), and LDH (lactate dehydrogenase) as renal dysfunction screening biomarkers in full and pre-term newborns treated wi...
متن کاملCircadian variation of gentamicin toxicity in rats.
OBJECTIVES/HYPOTHESIS Two undesired effects of the aminoglycoside antibiotic gentamicin are ototoxicity and nephrotoxicity. This study investigated if these adverse effects vary according to the circadian time of its administration. STUDY DESIGN This study entails laboratory animal research. METHODS Four groups of Sprague-Dawley rats were synchronized to a 12:12 light/dark schedule. Each gr...
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ژورنال
عنوان ژورنال: BMC Complementary and Alternative Medicine
سال: 2011
ISSN: 1472-6882
DOI: 10.1186/1472-6882-11-113